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Multidrug-Resistant Gram-Negative Bacilli
(MDR-GNB)
Gram-negative bacilli are
extremely common in healthcare settings, where they can either colonize or
infect patients. In recent years, multidrug-resistant gram-negative
organisms have increased in nearly all healthcare settings. Resistance
mainly occurs against the extended spectrum beta-lactam antimicrobial
agents, such as the penicillins, cephalosporins, and monobactams. This is
mainly due to the ability of these organisms to produce extended spectrum
beta lactamase enzymes (ESBLs). The most common MDR-GNB are Klebsiella,
E. coli, P. aeruginosa, and other Enterobacteriaceae.
Enterobacteriaceae are a large group of organism found in normal human
intestines. MDR-GNB can pose serious risks to patients and may warrant
intensified infection control measures.
Significant MDR-GNB:
·
Acinetobacter baumannii
·
Klebsiella pneumoniae
and other Carbapenem-Resistance
Enterobacteriaceae
(CRE)
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