Hepatitis B status can be determined using results of
several commonly ordered tests.
|
HBsAg
|
Anti-HBs
|
Anti-HBc
IgM
|
Anti-HBc IgG
|
Interpretation
|
| +
|
-
|
-
|
-
|
- early acute infection
- patient is infectious; consider vaccination for susceptible
household & sexual contacts
|
| +
|
-
|
+
|
+
|
- acute infection
- patient is infectious; consider vaccination for susceptible
household & sexual contacts
|
| +
|
-
|
-
|
+
|
- chronic infection
- patient
is infectious; patient should be evaluated for chronic liver disease;
vaccinate susceptible household & sexual contacts
|
| -
|
+
|
+/-
|
+
|
- resolved infection
- patient is immune
|
| -
|
-
|
+
|
-
|
- “window period” following acute infection
- patient is not infectious
|
| -
|
-
|
-
|
+
|
-
false positive anti-HBc
result
-
"window phase" of resolving
acute infection
-
late immunity stage
-
unresolved infection in late
or low grade state
-
patient is non-infectious in
most settings (household, sexual, needle stick exposures)
|
| -
|
+
|
-
|
-
|
- immune following vaccination; resolved infection with loss of detectable
anti-HBc
- patient is immune
|
