Epi-Update Weekly Publication of Bureau of Epidemiology

March 3, 2003


"The reason for 
collecting, analyzing and disseminating information on a disease is to control that disease. Collection and analysis should not be allowed to consume resources if action 
does not follow."

Foege WH et al. 
Int. J of Epidemiology
1976; 5:29-37



Epi Update 
Managing Staff

John Agwunobi, MD, MBA,
Secretary, Department of Health 

Landis Crockett, MD, MPH, 
Director, 
Division of Disease Control 

Steven T. Wiersma, MD, MPH,
Bureau Chief, 
State Epidemiologist 

Don Ward, 
Deputy Bureau Chief 
Epi Update Managing Editor 

Catherine Richards, 
Editorial Assistant 

Elizabeth Woodsmall,
Web Page Designer

This Week in the News:

Dr.  Blackmore Appointed as Acting Public Health Veterinarian
Dr. Carina Blackmore has been appointed acting, State Public Health Veterinarian.

Recruitment Open for Florida Epidemic Intelligence Service (FL-EIS) Class of 2003
The Florida-EIS  is a unique, two-year, post-graduate applied epidemiology program for health professionals under the direction of the Bureau of Epidemiology. It trains epidemiologists to assist county health departments in identifying and resolving disease outbreaks and to become leaders in the field of public health. 

Empyema Investigation Summary

On Wednesday, January 15, 2003, the Epidemiology Division received a telephone call from the Chief of Pediatric Infectious Diseases at a Northeast Florida hospital, expressing concern regarding an unusually large number of children presenting with complicated pneumonia/empyema.

Florida Youth Survey Trainings Held This Week
This will be the 6th annual survey administration, which began with the Florida Youth Tobacco Survey (FYTS) in 1998.  The 2003 survey window for complete administration is scheduled for March 17-April 30. 
 

Avian Influenza Confirmed in Hong Kong Residents
Two human cases of influenza A (H5N1) infection have been confirmed in a single family of Hong Kong residents who recently traveled to Fujian Province on mainland China.  This is the first time since 1997 that human influenza A (H5N1) cases have been identified anywhere in the world.

Influenza Virus Surveillance Summary Update
During week 7 (February 9-15, 2003) influenza activity, calculated based on the proportion of patients with influenza-like illness (ILI) seeking care by physicians participating in the Florida Sentinel Physicians Surveillance Network was 3.2%. This is the highest influenza activity reported so far this season and also higher than the national baseline of 1.9%.

Bureau of Epidemiology to Host CHD Conference Calls
Beginning on Friday, March 21, and on alternating Fridays thereafter, the Bureau of Epidemiology will host a scheduled conference call with county health department staff. 

Weekly Disease Table
Florida Department of Health, Bureau of Epidemiology,
Weekly Morbidity Report, Week 8, ending February 22, 2003
Selected Diseases and Conditions (Confirmed Cases Only)

A r t i c l e s:

   


Steven Wiersma, MD, MPH, State Epidemiologist and Chief, Bureau of Epidemiology

























Alan Rowan, PhD, MPA,  Program Manager, Florida Epidemic Intelligence Service








































































































Christine S. Cook, 
R.N., B.S.N., M.S.H., Government Operations Consultant II,
Duval County Health Dept 













































































Natalie Tackett, 
Bureau of Epidemiology




















Center for Disease Control



Submitted by:

Carina Blackmore, M.S. Vet. Med., Ph.D., Bureau of Epidemiology



































Carina Blackmore, M.S. Vet. Med., Ph.D., Bureau of Epidemiology











































Don Ward, Deputy Chief, Bureau of Epidemiology




  Dr.  Blackmore Appointed as Acting Public Health Veterinarian

I have appointed Dr. Carina Blackmore as Acting, State Public Health Veterinarian effective immediately.  Please refer any issues that Dr. Lisa Conti would have covered directly to Dr. Blackmore.  Dr. Blackmore will assume all of the responsibilities previously held by Dr. Lisa Conti prior to her move to the Division of Environmental Health.  

Dr. Carina Blackmore received her veterinarian training at the Swedish University of Agricultural Sciences in Uppsala and graduated in 1989.  She practiced large and small animal veterinary medicine until 1991.  She studied biological science at Notre Dame and graduated with a PhD in vector biology in 1996.  Her research was on the epidemiology of bunyaviruses in Indiana.  She taught biology, anatomy and physiology for two years at Valdosta State University in Valdosta, Georgia, before joining the Bureau of Epidemiology in 1998 as a Regional Epidemiologist based in Jacksonville.  Dr. Blackmore was previously the acting State Public Health Veterinarian during the first year of Florida’s WN virus epidemic, in 2001.  As Regional Epidemiologist she provides consultation to County Health Departments, primarily in NE Florida.  She also serves as the influenza surveillance coordinator, and has had important roles in outbreak response throughout the state.

Please join me in congratulating Carina for accepting these new challenges and in accomplishing her additional duties and in wishing Lisa the best in her new position.


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Recruitment Open for Florida Epidemic Intelligence Service (FL-EIS) Class of 2003

The Florida-EIS, headquartered at the Florida Department of Health in Tallahassee, is a unique, two-year, post-graduate applied epidemiology program for health professionals under the direction of the Bureau of Epidemiology. It will recruit and train epidemiologists to assist county health departments in identifying and resolving disease outbreaks and to become leaders in the field of public health. The long-term goal of this program is to increase the capacity of the Department of Health to respond to new challenges in disease control and prevention.

The Bureau of Epidemiology will provide salary and didactic training and participants will be matched with qualifying county health departments to spend their time working along with trained epidemiologists and public health professionals. There will be 6 openings for graduates of MPH programs and others who demonstrate similar skills and backgrounds. This program will provide a practical field epidemiology training program for successfully matched candidates. This program is modeled on the federal Centers for Disease Control and Prevention (CDC) EIS program and the California EIS program. The Bureau of Epidemiology has a long history of training CDC EIS officers who have gone on to hold senior positions in public health and other areas.

Participants will serve on the front line working side by side with local, state and federal investigators to: 
  • Conduct epidemiologic investigations, research, and public health surveillance; 
  • Present epidemiologic papers at scientific and medical conferences;
  • Publish their work in the scientific literature; 
  • Disseminate vital public health information to the media and the public
  • Florida EIS assignees have unique opportunities to apply training and skills to actual public health problems and issues; 
  • Establish mentorships with recognized experts from around the world; 
  • Attend training courses in computers, biostatistics and epidemiology. .

Eligibility criteria

Health professionals who meet one of the following qualifications and have a strong interest in applied epidemiology are eligible to apply to the Florida EIS:

  • Persons with a master's or doctoral degree in a health related field (e.g. MPH, PhD, DrPH) having taken at least one course in epidemiology and one course in (bio)statistics during graduate/professional school or persons with significant experience working in public health.
  • Physicians (MDs, DOs) with at least one year of clinical training and an active medical license in the U.S. (U.S. citizens or permanent residents).
  • Doctoral-degree recipients (PhDs, DrPHs, or equivalent) in health-related fields such as epidemiology, biostatistics, and the social behavioral, and nutritional sciences.
  • Nurses, dentists, and PharmDs, with a Master of Public Health (MPH) or equivalent degree and an active license in the U.S. (U.S. citizens or permanent residents).
  • Veterinarians with a Master of Public Health (MPH) or equivalent degree or demonstrated public health experience or course work, and an active license in the U.S. (U.S. citizens or permanent residents).

Stipends

Each trainee will receive a salary and benefits of approximately mid-$30K to mid-$40K per annum depending on experience. 

How to apply:

Requirements

  • Curriculum vitae in standard format 
  • Personal statement 
  • Three references 
  • Transcripts from highest degree granting programs 
  • Copy of U.S. clinical license (if applicable) 
  • Interviews in Tallahassee (offered to a limited number of applicants by invitation after prescreening of above materials.) 

Application timetable

  • March 28, 2003: Application for 2003 class
  • April 22 – 25, 2003: Orientation
  • May 19, 2003: Assignments begin

Mail application requirements to:

Florida Department of Health
4052 Bald Cypress Way, Bin #A-12
Prather Building, Room 320
Tallahassee, Florida 32399-1720


If you have questions about the program contact Dr. Alan Rowan at (850) 245-4444 Ext. 2442 or by e-mail to Alan_Rowan@doh.state.fl.us. 


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Empyema Investigation Summary


DCHD Epidemiology Division
January 31, 2003

Background
On Wednesday, January 15, 2003, the Epidemiology Division received a telephone call from the Chief of Pediatric Infectious Diseases at a Northeast Florida hospital, expressing concern regarding an unusually large number of children presenting with complicated pneumonia/empyema.  Reportedly, physicians at this hospital see approximately one case of pediatric thoracic empyema per month.  During the previous four weeks (range 12/10/02 – 01/15/03), seven children were hospitalized and treated for complicated pneumonia with pleural effusions, six of who were treated for empyema under the care of different physicians.  Empyema is a collection of pus in the pleural cavity (lining of the lung).  Most often, empyema is caused by Streptococcus pneumoniae, Haemophilus influenza or Staphylococcus aureus.  A VATS (video-assisted thoracic surgery) procedure is performed to remove the pus and damaged tissue, thus enabling the child to breathe better.  The case definition for inclusion into the investigation included all children with a diagnosis of complicated pneumonia with pleural effusions on x-ray.

Methods
Between Friday, January 17 and Tuesday, January 28, 2003, Epidemiology staff reviewed the medical records using the standard case report form with extra emphasis on lab results and treatment.  The record review process was lengthy, because two of the medical records were off site and had to be ordered.  When possible, parents of ill children were also personally interviewed by Epidemiology Division staff.

A database specific to empyema was created using Epi Info 2002, a statistical software program from the CDC.  The collected data was entered into the database and analyzed.  Surveillance for empyema was expanded to include other large hospitals in the state with pediatric clientele.

Findings

Enhanced surveillance:
No other clusters of empyema were identified in the state during the period of interest.

Data analyses:
Data analyses did not identify any links between cases.  Specific results are as follows:

Demographics:  Infected children ranged in age from 2 – 15 years.  Gender breakdown consisted of four males and three females.  Racial breakdown was six white children / one black child.  No children resided in the same zip code or attended the same school/daycare.  Only two of seven children had a history of daycare attendance.  One of seven children attended school.  Household size ranged from three to five members.  Two of seven children resided in households with a smoker.  Two out of seven children had pets.  One of seven children had a history of immunosuppression.  Two of seven children had history of travel outside of Northeast Florida in the month prior to illness onset.  One child had a history of airline travel to Michigan.  The second child had a history of travel to Orlando, FL to vacation at multiple theme parks.

Clinical/Laboratory data:  Three of seven children presented with sore throat prior to onset of pneumonia.  All children were admitted to the hospital between 12/10/2002-01/15/2003 with a diagnosis of pneumonia.  Most children were started on antibiotics prior to the collection of laboratory cultures.  Common antibiotic therapy (six out of seven children) included Rocephin and Vancomycin.  As a result, most cultures resulted in no growths.  Two children had laboratory tests indicative of Group A beta-hemolytic streptococcus.  One child was recovering from scarlet fever at the time of pneumonia onset.  She had a Quick Strep Ag (+).  Another child had a throat culture with a heavy growth of Group A Beta-Hemolytic Streptococcus.  Gram-positive cocci were seen on initial examination of lung tissue from these two patients, but the cultures failed to grow out.  Six out of seven children were diagnosed with empyema, resulting in a VATS procedure.  Two children required multiple VATS procedures.  Interestingly, each child presented with low hemoglobin <11 (normal range 14 – 17 depending on age) at some point during hospitalization.  Two children required blood transfusions.

Pt # Age (yrs) Gender VATS procedure (+)Strep Test Lowest

Hemoglobin

History of Immunosuppression
1 2 Male Yes Not done 10.1 No
2 4 Male Yes Yes 6.7 No
3 15 Male Yes Not done 11.0 No
4 5 Female Yes Yes 10.0 No
5 2 Male Yes Not done 8.4 No
6 6 Female No Not done 11.0 Yes
7 4 Female Yes Not done 6.1 No
Mean 5.4       9.0  

Discussion
Due to the small number of cases and lack of laboratory evidence, no link or common agent could be identified.  Enhanced surveillance will remain in effect for two months. 

Additional Reading

Byington, CL, Spencer, LY, Johnson, TA, Pavia, AT, et al.  An epidemiological investigation of a sustained high rate of pediatric parapneumonic empyema: risk factors and microbiological associations.  Clin Infect Dis 2002 Feb 15:34(4):434-40.

Cohen, G, Hjortdal, V, Ricci, M, Jaffe, A, Wallis, C, et al.  Primary thoracoscopic treatment of empyema in children.  J Thorac Cardiovas Surf 2003 Jan;125(1):79-84.

Lewis, RA, Feigin, RD.  Current issues in the diagnosis and management of pediatric empyema.  Semin Pediatr Infect Dis 2002 Oct;13(4):280-8.


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Florida Youth Survey Trainings Held This Week

Trainings for the upcoming 2003 Florida Youth Survey (FYS) were held February 24th and 25th in Orlando and Tallahassee respectively.  FYS Coordinators from 34 of the 41 selected counties were represented.  

This will be the 6th annual survey administration, which began with the Florida Youth Tobacco Survey (FYTS) in 1998.  The 2003 FYS will include four survey instruments: the FYTS, the Communities that Care/Florida Youth Substance Abuse Survey (CTC/FYSAS), the Youth Risk Behavior Survey (YRBS), which is administered to High School students only, and the newest addition to the survey effort, the Youth Physical Activity and Nutrition (YPAN) survey, which will be administered only in Middle Schools.

The 2003 survey window for complete administration is scheduled for March 17-April 30.  While data collection will be for state-wide numbers and not county-level data this year, the project is a considerable undertaking.  County coordinators were given instruction in the tedious administration process and will begin contacting their selected schools over the next two weeks.

For more information regarding the FYS 2003, please contact Natalie Tackett at 850/245-4444 x2440 or natalie_tackett@doh.state.fl.us.


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Avian Influenza Confirmed in Hong Kong Residents

Two human cases of influenza A (H5N1) infection have been confirmed in a single family of Hong Kong residents who recently traveled to Fujian Province on mainland China. The first patient, a 9-year-old boy, was hospitalized in Hong Kong but is recovering. The second patient, the father of the 9-year-old boy, died in a Hong Kong hospital on February 17. Additional family members had respiratory symptoms, and the boy's 8-year-old sister died while the family was in China. The cause of her death and of the other respiratory illnesses in her family is not known.

There is currently insufficient information to determine whether this family was infected from a common source or whether illness spread within the family from person to person. The Department of Health in Hong Kong SAR has intensified its surveillance for influenza among patients with influenza-like illness or atypical pneumonia. At present, levels of influenza activity in Hong Kong SAR are not unusual. In addition, there is currently no evidence of spread of influenza A (H5N1) infection from this family to contacts in China or Hong Kong or to their medical attendants. For more information, visit the Hong Kong Department of Health Web site (http://www.info.gov.hk/dh/new/bulletin/bullet.htm).

This is the first time since 1997 that human influenza A (H5N1) cases have been identified anywhere in the world. During the 1997 outbreak in Hong Kong, 18 people with influenza A(H5N1) infection were hospitalized and six of these patients died. Prior to 1997, influenza A (H5N1) had been found only in birds. During the 1997 outbreak in Hong Kong, transmission of the virus to people occurred primarily from direct contact with birds. Efficient, sustained transmission of the virus from person to person did not occur. Approximately 1.4 million chickens were destroyed in Hong Kong to remove the source of the virus. No further human cases of influenza A (H5N1)-related illness had been documented until February 2003, although H5N1 has periodically been detected in chickens and ducks, and more recently, in wild birds in Hong Kong. Additional information about the 1997 A (H5N1) outbreak can be found on the CDC website at
Update: Isolation of Avian Influenza A(H5N1) Viruses from Humans -- Hong Kong, 1997-1998 MMWR 46(52);1245-1247
and
Isolation of Avian Influenza A(H5N1) Viruses from Humans -- Hong Kong, May-December 1997 MMWR 46(50);1204-1207.

CDC is in communication with the World Health Organization (WHO) regarding these human cases of influenza A (H5N1) illness and will continue to monitor the situation. There is no indication that the virus has spread outside Asia. CDC and WHO have issued no restrictions on travel or trade to Hong Kong or China. Influenza activity in the United States is at moderate to high levels. Influenza A (H1N1), A (H1N2), A (H3N2), and influenza B viruses have been identified in the United States and all are well matched by the 2002-03 influenza vaccine. The current vaccine does not protect against infection with influenza A (H5N1) virus. U.S. residents who are traveling outside the United States should consult their physician for advice about whether they should be vaccinated against influenza and about the use of influenza antiviral medications.
 
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Influenza Virus Surveillance Summary Update

Week ending February 15, 2003-Week 7

Florida: During week 7 (February 9-15, 2003) influenza activity, calculated based on the proportion of patients with influenza-like illness (ILI) seeking care by physicians participating in the Florida Sentinel Physicians Surveillance Network was 3.2%. This is the highest influenza activity reported so far this season and also higher than the national baseline of 1.9%. Higher flu activity than expected for this time of year (>2%) was reported by physicians in Alachua, Brevard, Duval, Indian River, Leon, Levy, Okaloosa, Palm Beach and Polk counties. The influenza activity is wide spread. During the last three weeks over 65 laboratory confirmed influenza cases (primarily influenza A (H1N1) and influenza B) were reported from 15 counties across the state. This week influenza A H1N1 viruses were reported from Duval, Indian River and Madison counties, influenza A of unknown subtype from Duval and Pinellas counties and influenza B from Duval, Indian River and Leon counties. 

National report:
Four hundred fifty one isolates (207 influenza A and 244 influenza B viruses) were made from 2,527 specimens tested by the World Health Organization (WHO) and National Respiratory and Enteric Virus Surveillance System (NREVSS) collaborating laboratories this week. Since September 29, 7.9% (n=3,830) of the 42,652 specimens tested nationwide have been positive. Four hundred and eighty two (33%) of the 1,442 influenza A viruses have been subtyped; 409 were influenza A H1 viruses and 73 were influenza A (H3N2). Laboratory confirmed influenza has been reported from all 50 states. The majority of influenza B isolates (52%; n=1,247) were identified in Texas and Missouri. Influenza A viruses were reported more frequently than influenza B viruses (range 56%-86%) in the Mountain, East North Central, Pacific, and Mid-Atlantic regions. Influenza B were reported more frequently in the South Atlantic, West South Central and East South Central regions. CDC has characterized 45 influenza A (H1N1), 19 influenza A (H1N2), 28 influenza A (H3N2) and 86 influenza B isolates antigenically. All influenza A strains were similar to corresponding vaccine strains. One influenza B strain was more similar to B/Shizuoka/15/01 than to the vaccine strain (B/Hong Kong/ 330/01). The proportion of patient visits to sentinel physicians for influenza-like illness (ILI) was 3.0% nationwide. The State and Territorial Epidemiologists in eleven states (Colorado, Indiana, Iowa, Kansas, Missouri, North Carolina, Rhode Island, Tennessee, Texas Utah, Virginia and Wisconsin) reported widespread influenza activity. Flu outbreaks were reported in 23 additional states. Thirteen states reported sporadic influenza activity. The proportion of deaths attributed to pneumonia and influenza as reported by the vital statistics offices of 122 U.S. cities was 7.3% during week 7. This percentage is below the epidemic threshold of 8.3% for this time.

An avian flu virus strain, influenza A H5N1, has been recovered from two influenza cases in Hong Kong. CDC has issued recommendations on increased influenza surveillance in the United States. Of particular importance is to consider influenza cultures on patients, with recent travel histories to Asia, who are hospitalized with unexplained pneumonia, acute respiratory distress syndrome or severe respiratory illness.


For additional information on influenza and influenza surveillance results, please visit our website at http://www.doh.state.fl.us/disease_ctrl/epi/htopics/flu/index.htm

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Bureau of Epidemiology to Host CHD Conference Calls

Beginning on Friday, March 21, and on alternating Fridays thereafter, the Bureau of Epidemiology will host a scheduled conference call with county health department staff.  The purpose of the call is to update CHD staff on  Bureau activities and to discuss issues of mutual interest.  Each week’s agenda will be determined by input from the CHDs and Bureau staff. While the majority of agenda topics will probably be directed to surveillance and investigations, any other CHD/Epi topics are appropriate.  Any CHD staff are welcome to participate and staff conducting disease control activities are encouraged to attend.  The calls will use the technology employed in the Bureau’s Grand Rounds, that is, any presentation material will be posted on the intranet the day before the call. The bi-weekly “epi-calls” will begin at 10AM and last no longer than an hour.  The number for the call is  (850) 487-8587 or Suncom 277-8587.   Please e-mail suggestions for agenda items to Don Ward at donald_ward@doh.state.fl.us.  

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Weekly Disease Table : Week 8
Florida Department of Health, Bureau of Epidemiology
Weekly Morbidity Report, Week 8, ending  February 22, 2003
Selected Diseases and Conditions (Confirmed Cases Only)

www.doh.state.fl.us/disease_ctrl/epi/Disease%20Table/2003_weekly/diseasetable.htm


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